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About Us

About Us

MESSAGE

The human heart is an organ essential for sustaining life, continuously pumping blood throughout the body by repeating approximately 100,000 cycles of contraction and relaxation each day, amounting to nearly three billion beats over a lifetime. I have been deeply fascinated by this remarkable dynamism and have devoted my passion to cardiovascular research.

However, in exchange for its extraordinary functional demands, the human heart largely loses its capacity for cell division and proliferation, making self-regeneration extremely limited once injury occurs. Our research focuses on developing technologies to efficiently derive cardiomyocytes from human induced pluripotent stem cells (hiPSCs) and to construct functional cardiac tissues. By leveraging these technologies, we aim to establish regenerative therapies for intractable cardiovascular diseases.

Guided by the principles of passion, integrity, and creativity, our laboratory is committed not only to hiPSC-based cardiac regenerative therapies but also to exploring diverse approaches to develop novel treatments for cardiovascular diseases.

Let’s join us in pursuing research aimed at the fundamental cure of cardiovascular disease.

Prof.

Shugo Tohyama, MD, PhD

GALLERY

Research video

Human iPSC-cardiomyocytes before metabolic selection

Human iPSC-cardiomyocytes after metabolic selection

Time-lapse of cardiac spheroids formation

Time-lapse of metabolic selection

Cardiac fibers derived from human iPSCs

Engineered heart tissue derived from human iPSCs

Human iPSC-cardiomyocytes after metabolic selection

Cardiac spheroids derived from human iPSCs

Tubular engineered heart tissue derived from human iPSCs

Research picture

Engrafted cardiac tissue derived from human iPSCs
Engrafted cardiac tissue with neovascularization
Human iPSC-cardiomyocytes after metabolic selection
Coupling of engrafted cardiac tissue to the host myocardium
Cardiac organoids derived from human iPSCs

Other

A scene at FMiC
Travel Abstract Awards受賞(梅井)
Travel Abstract Awards

at ISSCR 2025 (Umei)
Young Investigator’s Award at the Japanese Circulation Society (Umei)
Young Investigator’s Award at the Japanese Tissue Culture Association (Moriwaki)
Young Investigator’s Award at the Japanese College of Cardiology (Sekine)
Young Investigator’s Award at the Japanese Society for Regenerative Medicine (Tani)
Kitasato Award at Keio University School of Medicine (Tohyama)
Congrats on publication in Biomaterials
Tohyama Lab Farewell Party 2024
FMiC at Haneda
tohyama Lab.
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