Publications

Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1. 

Naoko Shiba, Xiao Yang, Mitsuto Sato, Shin Kadota, Yota Suzuki, Masahiro Agata, Kohei Nagamine, Masaki Izumi, Yusuke Honda, Tomoya Koganehira, Hideki Kobayashi, Hajime Ichimura, Shinichiro Chuma, Junichi Nakai, Shugo Tohyama, Keiichi Fukuda, Daigo Miyazaki, Akinori Nakamura, Yuji Shiba

Molecular therapy. Nucleic acids 34 102060-102060, 12 December 2023

Scalable production of homogeneous cardiac organoids derived from human pluripotent stem cells 

Taijun Moriwaki, Hidenori Tani, Kotaro Haga, Yuika Morita-Umei, Yusuke Soma, Tomohiko C. Umei, Otoya Sekine, Kaworu Takatsuna, Yoshikazu Kishino, Hideaki Kanazawa, Jun Fujita, Keiichi Fukuda, Shugo Tohyama*, Masaki Ieda

Cell Reports Methods 3(12) 100666-100666, December 2023

Hydrogel-Sheathed HiPSC-Derived Heart Microtissue Enables Anchor-Free Contractile Force Measurement. 

Yuta Kurashina, Keisuke Fukada, Shun Itai, Shuichi Akizuki, Ryo Sato, Akari Masuda, Hidenori Tani, Jun Fujita, Keiichi Fukuda, Shugo Tohyama*, Hiroaki Onoe*

Advanced Science e2301831, 17 October 2023

Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin. 

Yuki Tanaka, Shin Kadota, Jian Zhao, Hideki Kobayashi, Satomi Okano, Masaki Izumi, Yusuke Honda, Hajime Ichimura, Naoko Shiba, Takeshi Uemura, Yuko Wada, Shinichiro Chuma, Tsutomu Nakada, Shugo Tohyama, Keiichi Fukuda, Mitsuhiko Yamada, Tatsuichiro Seto, Koichiro Kuwahara, Yuji Shiba

Stem cell research & therapy 14(1) 240-240, 07 September 2023

Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells. 

Otoya Sekine, Sayaka Kanaami, Kanako Masumoto, Yuki Aihara, Yuika Morita-Umei, Hidenori Tani, Yusuke Soma, Tomohiko C Umei, Kotaro Haga, Taijun Moriwaki, Yujiro Kawai, Masatoshi Ohno, Yoshikazu Kishino, Hideaki Kanazawa, Keiichi Fukuda, Masaki Ieda, Shugo Tohyama*

Stem Cell Reports, 31 August 2023

PRESS RELEASE

Heart-derived collagen promotes maturation of engineered heart tissue. 

Hidenori Tani, Eiji Kobayashi, Shinomi Yagi, Keisuke Tanaka, Kotaro Kameda-Haga, Shinsuke Shibata, Nobuko Moritoki, Kaworu Takatsuna, Taijun Moriwaki, Otoya Sekine, Tomohiko C Umei, Yuika Morita, Yusuke Soma, Yoshikazu Kishino, Hideaki Kanazawa, Jun Fujita, Shunji Hattori, Keiichi Fukuda, Shugo Tohyama*

Biomaterials 299 122174-122174, August 2023

PRESS RELEASE

Cardiac Regenerative Therapy Using Human Pluripotent Stem Cells for Heart Failure: A State-of-the-Art Review. 

Yoshikazu Kishino, Shugo Tohyama*, Yuika Morita, Yusuke Soma, Hidenori Tani, Marina Okada, Hideaki Kanazawa, Keiichi Fukuda

Journal of cardiac failure 29(4) 503-513, April 2023

An Approach That Brings Out the Potential of Regenerative Therapies in Heart Failure. 

Yoshikazu Kishino, Shugo Tohyama*

Circulation journal : official journal of the Japanese Circulation Society 87(4) 487-489, 24 March 2023

Metabolism-based cardiomyocytes production for regenerative therapy. 

Tomohiko C Umei, Shugo Tohyama*, Keiichi Fukuda

Journal of molecular and cellular cardiology 176 11-20, 01 March 2023