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English
2025
Development and Application of 3D Cardiac Tissues Derived from Human Pluripotent Stem Cells
Drug Metabolism and Pharmacokinetics 60 101049-101049, 4 January 2025
2024
Metabolic changes of human induced pluripotent stem cell-derived cardiomyocytes and teratomas after transplantation
iScience 27(11) 111234-111234, November 2024
Maturation of Human iPSC-Derived Cardiac Microfiber with Electrical Stimulation Device
Advanced healthcare materials 13(27) e2303477, 29 May 2024
Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.
Circulation 150(8) 611-621, 26 April 2024
H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency.
Stem cell reports 19(5) 710-728, 23 April 2024
Pluripotent stem cell-based cardiac regenerative therapy for heart failure.
Journal of molecular and cellular cardiology 187 90-100, February 2024
2023
Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.
Molecular therapy. Nucleic acids 34 102060-102060, 12 December 2023
Scalable production of homogeneous cardiac organoids derived from human pluripotent stem cells
Cell Reports Methods 3(12) 100666-100666, December 2023
Hydrogel-Sheathed HiPSC-Derived Heart Microtissue Enables Anchor-Free Contractile Force Measurement.
Advanced Science e2301831, 17 October 2023
Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.
Stem cell research & therapy 14(1) 240-240, 07 September 2023
Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells.
Stem Cell Reports, 31 August 2023
Heart-derived collagen promotes maturation of engineered heart tissue.
Biomaterials 299 122174-122174, August 2023
Cardiac Regenerative Therapy Using Human Pluripotent Stem Cells for Heart Failure: A State-of-the-Art Review.
Journal of cardiac failure 29(4) 503-513, April 2023
An Approach That Brings Out the Potential of Regenerative Therapies in Heart Failure.
Circulation journal : official journal of the Japanese Circulation Society 87(4) 487-489, 24 March 2023
Metabolism-based cardiomyocytes production for regenerative therapy.
Journal of molecular and cellular cardiology 176 11-20, 01 March 2023
2022
Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration.
Journal of molecular and cellular cardiology 174 77-87, 18 October 2022
Purification of cardiomyocytes and neurons derived from human pluripotent stem cells by inhibition of de novo fatty acid synthesis.
STAR Protocols 3(2) 101360-101360, 17 June 2022
Protocol for enhanced proliferation of human pluripotent stem cells in tryptophan-fortified media.
STAR Protocols 3(2) 101341-101341, 17 June 2022
Scalable manufacturing of clinical-grade differentiated cardiomyocytes derived from human-induced pluripotent stem cells for regenerative therapy.
Cell proliferation e13248, 09 May 2022
Metabolism in Human Pluripotent Stem Cells and Cardiomyocytes for Regenerative Therapy.
The Keio journal of medicine, 25 January 2022
Scaffold-Free Tubular Engineered Heart Tissue From Human Induced Pluripotent Stem Cells Using Bio-3D Printing Technology in vivo.
Frontiers in cardiovascular medicine 8 806215-806215, 20 January 2022
Human Engineered Heart Tissue Models for Disease Modeling and Drug Discovery.
Frontiers in cell and developmental biology 10 855763-855763, 2022
Clinical Application of iPSC-Derived Cardiomyocytes in Patients with Advanced Heart Failure
Advanced Technologies in Cardiovascular Bioengineering, Springer 361-374, January 2022
2021
The Present State and Future Perspectives of Cardiac Regenerative Therapy Using Human Pluripotent Stem Cells.
Frontiers in cardiovascular medicine 8 774389-774389, 08 December 2021
Production of functional cardiomyocytes and cardiac tissue from human induced pluripotent stem cells for regenerative therapy.
Journal of molecular and cellular cardiology 164 83-91, 22 November 2021
Intramyocardial Transplantation of Human iPS Cell-Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals.
JACC. Basic to translational science 6(3) 239-254, March 2021
Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells.
iScience 24(2) 102090-102090, 19 February 2021
Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes.
Inflammation and regeneration 41(1) 5-5, 01 February 2021
A Method for Cardiac Differentiation, Purification, and Cardiac Spheroid Production of Human Induced Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.) 2320 11-21, 2021
2020
Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells.
iScience 23(9) 101535-101535, 01 September 2020
Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
Scientific reports 10(1) 11883-11883, 17 July 2020
Metabolic Regulation of Cardiac Differentiation and Maturation in Pluripotent Stem Cells: A Lesson from Heart Development.
JMA journal 3(3) 193-200, 15 July 2020
Organ Fabrication Using Pigs as An in Vivo Bioreactor.
The Keio journal of medicine 69(2) 30-36, 25 June 2020
Cost-effective culture of human induced pluripotent stem cells using UV/ozone-modified culture plastics with reduction of cell-adhesive matrix coating.
Materials science & engineering. C, Materials for biological applications 111 110788-110788 , June 2020
Toward the realization of cardiac regenerative medicine using pluripotent stem cells.
Inflammation and regeneration 40 1-1, 2020
2019
An effective detachment system for human induced pluripotent stem cells cultured on multilayered cultivation substrates using resonance vibrations.
Scientific reports 9(1) 15655-15655, 30 October 2019
Concise Review: Genetic and Epigenetic Regulation of Cardiac Differentiation from Human Pluripotent Stem Cells.
Stem cells (Dayton, Ohio) 37(8) 992-1002, August 2019
Selective elimination of undifferentiated human pluripotent stem cells using pluripotent state-specific immunogenic antigen Glypican-3.
Biochemical and biophysical research communications 511(3) 711-717, 09 April 2019
Development of a transplant injection device for optimal distribution and retention of human induced pluripotent stem cell‒derived cardiomyocytes.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 38(2) 203-214, February 2019
Age-Appropriateness of Porcine Models Used for Cell Transplantation.
Cell transplantation 28(2) 224-228, February 2019
2018
Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.
Cell stem cell 23(3) 382-395, 06 September 2018
2017
Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes.
Stem Cell Reports 9(5) 1406-1414, 14 November 2017
Epigenetic barrier against the propagation of fluctuating gene expression in embryonic stem cells
FEBS LETTERS 591(18) 2879-2889, 01 September 2017
Safe and Effective Cardiac Regenerative Therapy With Human-Induced Pluripotent Stem Cells: How Should We Prepare Pure Cardiac Myocytes?
Circulation Research 120(10) 1558-1560, 12 May 2017
Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient.
Scientific reports 7 44312-44312, 14 March 2017
Cryoinjury-induced acute myocardial infarction model and ameroid constrictor-induced ischemic heart disease model in adult micro-mini pigs for preclinical studies.
Translational Medicine Communications 2(1), 01 February 2017
Enhancing Survival of Human Hepatocytes by Neonatal Thymectomy and Partial Hepatectomy in Micro-miniature Pigs
TRANSPLANTATION PROCEEDINGS 49(1) 153-158, January 2017
Manipulation of Pluripotent Stem Cell Metabolism for Clinical Application.
Current stem cell reports 3(1) 28-34 , 2017
2016
ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism.
Nature communications 7 13016-13016, 28 September 2016
H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.
Stem cell reports 6(6) 825-833, 14 June 2016
Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.
Cell Metabolism 23(4) 663-74, 12 April 2016
Patient-Specific Induced Pluripotent Stem Cell Models: Characterization of iPS Cell-Derived Cardiomyocytes.
Methods in molecular biology (Clifton, N.J.) 1353 343-53, 2016
Future Treatment of Heart Failure Using Human iPSC-Derived Cardiomyocytes
Etiology and Morphogenesis of Congenital Heart Disease 25-31, 2016
2015
Analysis of cardiomyocyte movement in the developing murine heart.
Biochemical and biophysical research communications 464(4) 1000-1007, 04 September 2015
G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy.
Nature communications 6 6745-6745, 13 April 2015
Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels.
FEBS open bio 5 219-25, 2015
Gelatin Hydrogel Enhances the Engraftment of Transplanted Cardiomyocytes and Angiogenesis to Ameliorate Cardiac Function after Myocardial Infarction.
PloS one 10(7) e0133308, 2015
The Prevalence of Clinically Significant Ischemia in Patients Undergoing Percutaneous Coronary Intervention: A Report from the Multicenter Registry.
PloS one 10(7) e0133568, 2015
2014
A massive suspension culture system with metabolic purification for human pluripotent stem cell-derived cardiomyocytes.
Stem cells translational medicine 3(12) 1473-83, December 2014
MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures.
The EMBO journal 33(14) 1565-81, 17 July 2014
Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte.
Journal of molecular and cellular cardiology 72 241-9 , July 2014
Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2.
Hypertension (Dallas, Tex. : 1979) 63(1) 80-7, January 2014
Generation and characterization of functional cardiomyocytes derived from human T cell-derived induced pluripotent stem cells.
PloS one 9(1) e85645, 2014
Derivation of transgene-free human induced pluripotent stem cells from human peripheral T cells in defined culture conditions.
PloS one 9(5) e97397, 2014
2013
Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.
Proceedings of the National Academy of Sciences of the United States of America 110(31) 12667-72, 30 July 2013
Distinct iPS Cells Show Different Cardiac Differentiation Efficiency
STEM CELLS INTERNATIONAL 2013 659739, 2013
Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes.
Cell Stem Cell 12(1) 127-37, 03 January 2013
Distinct iPS Cells Show Different Cardiac Differentiation Efficiency.
Stem cells international 2013 659739-659739, 2013
2012
Myocardial cell sheet therapy and cardiac function.
American journal of physiology. Heart and circulatory physiology 303(10) H1169-82-1182, 15 November 2012
miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish.
Biochemical and biophysical research communications 425(4) 755-61, 07 September 2012
Disease characterization using LQTS-specific induced pluripotent stem cells.
Cardiovascular research 95(4) 419-29, 01 September 2012
2011
The Overexpression of S105N Mutant Rad Leads Intracellular Ca2+ Overload Via Up-Regulation of Cardiac Ryanodine Receptor Activity
Journal of Arrhythmia 27 OP32_5, 2011
Simple autogeneic feeder cell preparation for pluripotent stem cells.
Stem cell research 6(1) 83-9 , January 2011
2010
Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.
Cell Stem Cell 7(1) 11-4 , 02 July 2010
Impacts of recent advances in cardiovascular regenerative medicine on clinical therapies and drug discovery.
Pharmacology & therapeutics 126(2) 109-18, May 2010
Nongenetic method for purifying stem cell-derived cardiomyocytes.
Nature methods 7(1) 61-6 , January 2010
2009
In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes.
Biochemical and biophysical research communications 385(4) 497-502, 07 August 2009
Japanese
2024
患者まで届いている再生医療 難治性重症心不全患者を対象とした同種iPS細胞由来心筋スフェロイド移植
再生医療 23(2) 78-83, May 2024
三次元新組織の開発とその応用
実験医学 42(5) 728-735, March 2024
成熟度の高いオルガノイドを試験管内でいかに作り上げるか? ブタ臓器特異的細胞外基質の特性と心臓由来コラーゲンの利用
Organ Biology 31(1) 012-016, 2024
【心不全の最新治療-再生医療を用いた最新の知見】培養液を利用したヒトiPS細胞由来心筋細胞の大量選別法と品質評価法の開発
カレントテラピー 42(1) 20-25, January 2024
2022
多能性幹細胞における代謝機構に基づく心筋再生治療法の開発
日本心不全学会 eLetter 2022年夏号, June 2022
2021
ヒト多能性幹細胞の増殖促進法
実験医学 39(16) 2605-2610, October 2021
細胞代謝機構に基づく選別を活用した臨床応用戦略
細胞 53(11) 9-12, September 2021
心臓再生医療に向けた基礎研究と臨床応用
心臓 53(7) 671-676, July 2021
2020
細胞内代謝機構に基づくヒトiPS細胞由来心筋作製と心臓再生医療への応用
心臓 52(2) 227-232, February 2020
心筋再生医療の現状と今後の展望
循環器内科 87(4) 432-438, 2020
【U40世代が描く心不全診療の現状と未来-基礎研究を識り,臨床を素心深考する】基礎研究から知る臨床の未来 心筋再生はどこまで進んでいるの?
循環器ジャーナル 68(1) 165-169, January 2020
2019
【再生医療up to date】【多次元構造臓器の再生】ヒトiPS細胞由来微小心筋組織球の大量製造法の開発
腎と透析 86(3) 285-290, March 2019
【心不全のサイエンス 治療法開発をめざして心臓の謎を解く】(第2章)心疾患・心不全の分子病態の最先端 発生および分化における代謝シフトと可塑性
実験医学 37(5) 712-718, March 2019
2018
ヒトiPS細胞を用いた心臓再生医療の現状と今後の展望
日本臨床 76 38‐44, 31 December 2018
2次元培養系によるヒトiPS細胞由来心筋細胞の大量作製
Bio Industry 35(8) 14‐21, 12 August 2018
臨床応用前夜となったヒトiPS細胞を用いた心臓再生医療
医工学治療 30(Suppl.) 47-47, 01 March 2018
2017
創薬シリーズ 創薬研究の新潮流 分化心筋細胞を用いた重症心不全における再生医療研究
日本薬理学雑誌 150(5) 246-250, November 2017
再生医療・遺伝子治療 ヒトiPS細胞を用いた心臓再生医療実現化における現状と課題
Cardiac Practice 28(3) 181‐185, 30 July 2017
ヒト多能性幹細胞および分化心筋細胞における代謝環境への適応能
適応医学 20(2) 8‐14, 10 July 2017
【再生医療・遺伝子治療】 基礎 ヒトiPS細胞を用いた心臓再生医療実現化における現状と課題
Cardiac Practice 28(3) 181-185, July 2017
ヒト多能性幹細胞および分化心筋細胞における代謝環境への適応能
適応医学 20(2) 8-14, July 2017
心筋再生医療 前臨床研究から臨床応用へ向けた課題とその克服
糖尿病 60(Suppl.1) S-5, April 2017
代謝を利用したヒトiPS細胞由来心筋細胞におけるふるい分け技術の確立
再生医療 16, 2017
2016
ヒト多能性幹細胞におけるグルタミン代謝の役割と再生医療への応用
月刊臨床免疫・アレルギー科 66(6) 627‐632-632, 25 December 2016
ヒト多能性幹細胞におけるグルタミン代謝の役割と再生医療への応用
臨床免疫・アレルギー科 66(6) 627-632, December 2016
20年後の再生医療を予測する 循環器領域へのiPS細胞の臨床応用の現状
循環器専門医 24(2) 242-251, August 2016
iPS細胞を用いた循環器領域の再生医療
日本内科学会雑誌 105(7) 1287‐1295, 10 July 2016
ヒト多能性幹細胞におけるグルタミン代謝を利用した心臓再生医療
日本分子生物学会年会プログラム・要旨集(Web) 39th, 2016
2015
心筋再生の現状と展望 ヒトiPS細胞由来分化細胞における未分化幹細胞除去と心筋純化精製
最新医学 70(8) 1618-1624, 10 August 2015
【心筋再生の現状と展望】 ヒトiPS細胞由来分化細胞における未分化幹細胞除去と心筋純化精製
最新医学 70(8) 1618-1624, August 2015
【再生医療2015 幹細胞と疾患iPS細胞の研究最前線】 (第3章)疾患iPS細胞 疾患特異的ヒトiPS細胞由来心筋細胞を用いた遺伝性循環器疾患解析
実験医学 33(2) 292-298, February 2015
疾患iPS細胞 3.疾患特異的ヒトiPS細胞由来心筋細胞を用いた遺伝性循環器疾患解析
実験医学 33(2) 292-298, 01 February 2015
代謝的アプローチによるヒトES/iPS細胞を用いた心臓再生医療
再生医療 14, 2015
代謝制御を基盤とした心臓再生医療
日本血管生物医学会学術集会プログラム・抄録集 23rd, 2015
2014
心臓再生医療で乗り越えなければならないハードルとは―心臓再生医療における現状と課題
循環器内科 76(5) 500-505, 28 November 2014
心臓再生医療で乗り越えなければならないハードルとは-心臓再生医療における現状と課題
循環器内科 76(5) 500-505, November 2014
ゼラチンハイドロゲルを使用した,不全心に対する心筋細胞移植による急性期機能改善と移植効率の検討
日本心臓病学会学術集会抄録(CD-ROM) 62nd ROMBUNNO.P-537-537, 02 September 2014
代謝的アプローチによるESおよびiPS細胞における未分化幹細胞除去法および心筋精製法
Cytometry Research 24(1) 1-6, 25 April 2014
発生学・再生学シリーズ 網羅的代謝解析の再生医学への応用
血管医学 14(4) 435-441, 20 February 2014
心臓移植治療の現在
Medicina 51(2) 370-376, 10 February 2014
2013
【循環器再生医療の現状と展望】 メタボローム解析を利用したES・iPS由来心筋細胞における純化精製法の確立
Circulation 3(9) 47-53, September 2013
【細胞移植】 ヒトESおよびiPS細胞を用いた心臓再生医療の課題と展望
細胞 45(7) 319-322, July 2013
心不全の基礎と臨床 重症心不全における心臓再生医療
月刊メディカル・サイエンス・ダイジェスト 39(7) 314-317, 30 June 2013
iPS細胞の純化・安全性 ES細胞およびiPS細胞における未分化幹細胞除去法および心筋精製法
Cytometry Research 23(Suppl.) 50-50, June 2013
iPS細胞の現状と近未来 メタボローム解析を用いたヒトES/iPS由来心筋細胞における純化精製法の確立
日本DDS学会学術集会プログラム予稿集 29回 66-66, 01 June 2013
慢性呼吸器疾患:ベッドサイドの運動負荷試験―実践と理論 基礎医学とのダイアローグ ESおよびiPS細胞由来心筋細胞における代謝の特性を利用した大量精製法
THE LUNG-perspectives 21(2) 179-182, 01 May 2013
2012
ES/iPS細胞由来心筋細胞における代謝的精製法の構築
心臓 44(12) 1636-1636, December 2012
幹細胞の臨床応用 ES/iPS由来心筋細胞を用いた心臓再生医療
月刊メディカル・サイエンス・ダイジェスト 38(11) 483-485, 25 October 2012
ヒトiPS由来心筋の電気生理学的性質におよぼす分化誘導時間の影響
日本薬学会年会要旨集 132年会(3) 175-175, March 2012
代謝の特性を利用したヒトES/iPS由来心筋細胞精製法
血管 35(1) 19, 31 January 2012
再生医療研究の最先端 代謝の特性を利用したヒトES/iPS由来心筋細胞精製法
血管 35(1) 19-19, January 2012
2011
iPS細胞の電気生理学 心電学への応用とその将来展望 ヒトiPS細胞由来心筋細胞の電気生理学 パッチクランプ実験
心電図 31(3) 325-328, August 2011
2010
ヒトiPS由来心筋細胞の電気生理学的特性について
心電図 30(Suppl.4) S-4, September 2010
2009
iPS細胞の創薬研究への利用 循環器疾患とiPS細胞
月刊メディカル・サイエンス・ダイジェスト 35(12) 497-500, 31 October 2009
「移植医療におけるiPS細胞研究のインパクト」ES細胞・iPS細胞からの心筋細胞分化・精製・移植
移植 44(3) 219-225, 10 June 2009