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Metabolic changes of human induced pluripotent stem cell-derived cardiomyocytes and teratomas after transplantation 

Yusuke Soma, Shugo Tohyama*, Akiko Kubo, Tomoteru Yamasaki, Noriko Kabasawa, Kotaro Haga, Hidenori Tani, Yuika Morita-Umei, Tomohiko C. Umei, Otoya Sekine, Masashi Nakamura, Taijun Moriwaki, Sho Tanosaki, Shota Someya, Yujiro Kawai, Masatoshi Ohno, Yoshikazu Kishino, Hideaki Kanazawa, Jun Fujita, Ming-Rong Zhang, Makoto Suematsu, Keiichi Fukuda, Masaki Ieda

iScience 27(11) 111234-111234, November 2024

Maturation of Human iPSC-Derived Cardiac Microfiber with Electrical Stimulation Device 

Akari Masuda, Yuta Kurashina, Hidenori Tani, Yusuke Soma, Jumpei Muramatsu, Shun Itai, Shugo Tohyama*, Hiroaki Onoe*

Advanced healthcare materials 13(27) e2303477, 29 May 2024

Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids. 

Hideki Kobayashi, Shugo Tohyama*, Hajime Ichimura, Noburo Ohashi, Shuji Chino, Yusuke Soma, Hidenori Tani, Yuki Tanaka, Xiao Yang, Naoko Shiba, Shin Kadota, Kotaro Haga, Taijun Moriwaki, Yuika Morita-Umei, Tomohiko C Umei, Otoya Sekine, Yoshikazu Kishino, Hideaki Kanazawa, Hiroyuki Kawagishi, Mitsuhiko Yamada, Kazumasa Narita, Takafumi Naito, Tatsuichiro Seto, Koichiro Kuwahara, Yuji Shiba*, Keiichi Fukuda

Circulation 150(8) 611-621, 26 April 2024

PRESS RELEASE

Scalable production of homogeneous cardiac organoids derived from human pluripotent stem cells 

Taijun Moriwaki, Hidenori Tani, Kotaro Haga, Yuika Morita-Umei, Yusuke Soma, Tomohiko C. Umei, Otoya Sekine, Kaworu Takatsuna, Yoshikazu Kishino, Hideaki Kanazawa, Jun Fujita, Keiichi Fukuda, Shugo Tohyama*, Masaki Ieda

Cell Reports Methods 3(12) 100666-100666, December 2023

Hydrogel-Sheathed HiPSC-Derived Heart Microtissue Enables Anchor-Free Contractile Force Measurement. 

Yuta Kurashina, Keisuke Fukada, Shun Itai, Shuichi Akizuki, Ryo Sato, Akari Masuda, Hidenori Tani, Jun Fujita, Keiichi Fukuda, Shugo Tohyama*, Hiroaki Onoe*

Advanced Science e2301831, 17 October 2023

Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells. 

Otoya Sekine, Sayaka Kanaami, Kanako Masumoto, Yuki Aihara, Yuika Morita-Umei, Hidenori Tani, Yusuke Soma, Tomohiko C Umei, Kotaro Haga, Taijun Moriwaki, Yujiro Kawai, Masatoshi Ohno, Yoshikazu Kishino, Hideaki Kanazawa, Keiichi Fukuda, Masaki Ieda, Shugo Tohyama*

Stem Cell Reports, 31 August 2023

PRESS RELEASE

Heart-derived collagen promotes maturation of engineered heart tissue. 

Hidenori Tani, Eiji Kobayashi, Shinomi Yagi, Keisuke Tanaka, Kotaro Kameda-Haga, Shinsuke Shibata, Nobuko Moritoki, Kaworu Takatsuna, Taijun Moriwaki, Otoya Sekine, Tomohiko C Umei, Yuika Morita, Yusuke Soma, Yoshikazu Kishino, Hideaki Kanazawa, Jun Fujita, Shunji Hattori, Keiichi Fukuda, Shugo Tohyama*

Biomaterials 299 122174-122174, August 2023

PRESS RELEASE

Purification of cardiomyocytes and neurons derived from human pluripotent stem cells by inhibition of de novo fatty acid synthesis. 

Sho Tanosaki, Tomohiko Akiyama, Sayaka Kanaami, Jun Fujita, Minoru S H Ko, Keiichi Fukuda, Shugo Tohyama*

STAR Protocols 3(2) 101360-101360, 17 June 2022

Protocol for enhanced proliferation of human pluripotent stem cells in tryptophan-fortified media. 

Kotaro Kameda, Shota Someya, Jun Fujita, Keiichi Fukuda, Shugo Tohyama*

STAR Protocols 3(2) 101341-101341, 17 June 2022

Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells. 

Shota Someya, Shugo Tohyama*, Kotaro Kameda, Sho Tanosaki, Yuika Morita, Kazunori Sasaki, Moon-Il Kang, Yoshikazu Kishino, Marina Okada, Hidenori Tani, Yusuke Soma, Kazuaki Nakajima, Tomohiko Umei, Otoya Sekine, Taijun Moriwaki, Hideaki Kanazawa, Eiji Kobayashi, Jun Fujita, Keiichi Fukuda

iScience 24(2) 102090-102090, 19 February 2021

PRESS RELEASE

Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells. 

Sho Tanosaki, Shugo Tohyama*, Jun Fujita, Shota Someya, Takako Hishiki, Tomomi Matsuura, Hiroki Nakanishi, Takayo Ohto-Nakanishi, Tomohiko Akiyama, Yuika Morita, Yoshikazu Kishino, Marina Okada, Hidenori Tani, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Masahiro Sugimoto, Minoru S H Ko, Makoto Suematsu, Keiichi Fukuda

iScience 23(9) 101535-101535, 01 September 2020

PRESS RELEASE

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification. 

Taketaro Sadahiro, Mari Isomi, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Fumiya Tamura, Hidenori Tani, Shugo Tohyama, Jun Fujita, Hiroyuki Miyoshi, Yoshifumi Kawamura, Naoki Goshima, Yuka W Iwasaki, Kensaku Murano, Kuniaki Saito, Mayumi Oda, Peter Andersen, Chulan Kwon, Hideki Uosaki, Hirofumi Nishizono, Keiichi Fukuda, Masaki Ieda

Cell stem cell 23(3) 382-395, 06 September 2018

Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes. 

Shugo Tohyama, Jun Fujita, Chihana Fujita, Miho Yamaguchi, Sayaka Kanaami, Rei Ohno, Kazuho Sakamoto, Masami Kodama, Junko Kurokawa, Hideaki Kanazawa, Tomohisa Seki, Yoshikazu Kishino, Marina Okada, Kazuaki Nakajima, Sho Tanosaki, Shota Someya, Akinori Hirano, Shinji Kawaguchi, Eiji Kobayashi, Keiichi Fukuda

Stem Cell Reports 9(5) 1406-1414, 14 November 2017

PRESS RELEASE

Safe and Effective Cardiac Regenerative Therapy With Human-Induced Pluripotent Stem Cells: How Should We Prepare Pure Cardiac Myocytes? 

Shugo Tohyama*, Keiichi Fukuda

Circulation Research 120(10) 1558-1560, 12 May 2017

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells. 

Shugo Tohyama, Jun Fujita, Takako Hishiki, Tomomi Matsuura, Fumiyuki Hattori, Rei Ohno, Hideaki Kanazawa, Tomohisa Seki, Kazuaki Nakajima, Yoshikazu Kishino, Marina Okada, Akinori Hirano, Takuya Kuroda, Satoshi Yasuda, Yoji Sato, Shinsuke Yuasa, Motoaki Sano, Makoto Suematsu, Keiichi Fukuda

Cell Metabolism 23(4) 663-74, 12 April 2016

PRESS RELEASE

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes. 

Shugo Tohyama, Fumiyuki Hattori, Motoaki Sano, Takako Hishiki, Yoshiko Nagahata, Tomomi Matsuura, Hisayuki Hashimoto, Tomoyuki Suzuki, Hiromi Yamashita, Yusuke Satoh, Toru Egashira, Tomohisa Seki, Naoto Muraoka, Hiroyuki Yamakawa, Yasuyuki Ohgino, Tomofumi Tanaka, Masatoshi Yoichi, Shinsuke Yuasa, Mitsushige Murata, Makoto Suematsu, Keiichi Fukuda

Cell Stem Cell 12(1) 127-37, 03 January 2013

Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. 

Tomohisa Seki, Shinsuke Yuasa, Mayumi Oda, Toru Egashira, Kojiro Yae, Dai Kusumoto, Hikari Nakata, Shugo Tohyama, Hisayuki Hashimoto, Masaki Kodaira, Yohei Okada, Hiroyuki Seimiya, Noemi Fusaki, Mamoru Hasegawa, Keiichi Fukuda

Cell Stem Cell 7(1) 11-4 , 02 July 2010

Nongenetic method for purifying stem cell-derived cardiomyocytes. 

Fumiyuki Hattori, Hao Chen, Hiromi Yamashita, Shugo Tohyama, Yu-Suke Satoh, Shinsuke Yuasa, Weizhen Li, Hiroyuki Yamakawa, Tomofumi Tanaka, Takeshi Onitsuka, Kenichiro Shimoji, Yohei Ohno, Toru Egashira, Ruri Kaneda, Mitsushige Murata, Kyoko Hidaka, Takayuki Morisaki, Erika Sasaki, Takeshi Suzuki, Motoaki Sano, Shinji Makino, Shinzo Oikawa, Keiichi Fukuda

Nature methods 7(1) 61-6 , January 2010